Patient-Reported Outcomes Measurement Information System Global Health (PGH) was validated to assess health-related quality of life (HRQOL) in several diseases. Little is known about its measurement properties in adult atopic dermatitis (AD).Examine the measurement properties of PGH in adult AD.A prospective dermatology-practice based study of 994 AD patients (age 18-97 years).PGH physical and mental health 4-item and abridged 2-item T-scores, and mapped EQ-5D showed strong to very strong correlation with each other, and moderate-strong Spearman correlations with PO-SCORAD, PHQ9, PROMIS sleep disturbance and related-impairment, EASI, objective-SCORAD, weak-moderate correlations with POEM, NRS worst-itch and average-itch, and SCORAD. DLQI had stronger correlations with POEM, PO-SCORAD, NRS worst-itch and average-itch, EASI and SCORAD, but weaker correlations with PHQ9 and PROMIS sleep disturbance and related-impairment (convergent/divergent validity). PGH and DLQI scores had similarly poor ability to differentiate between levels of self-reported global AD severity (known-groups validity). No floor or ceiling effects were observed. No PGH or DLQI items suffered from differential item functioning by demographics. PGH and DLQI scores showed fair-good responsiveness. Finally, PGH and DLQI showed similarly good test-retest reliability.Single-center study.PGH scores had sufficient validity and reliability to assess HRQOL in AD.