Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation.

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BK virus-associated hemorrhagic cystitis (BKV-HC) is a common complication of allogenic hematopoietic stem cell transplantation (AHSCT), particularly in recipients of alternative donor transplants, which are being performed in increasing numbers. BKV-HC typically results in painful hematuria, urinary obstruction, and renal dysfunction, without a definitive therapeutic option.We performed a clinical trial (ClinicalTrials.gov identifier: NCT02479698) to assess the feasibility, safety, and efficacy of administering most closely HLA-matched third-party BKV-specific cytotoxic T lymphocytes (CTLs), generated from 26 healthy donors and banked for off-the-shelf use. The cells were infused into 59 patients who developed BKV-HC following AHSCT. Comprehensive clinical assessments and correlative studies were performed.Response to BKV-CTL infusion was rapid; the day 14 overall response rate was 67.7% (40 of 59 evaluable patients), which increased to 81.6% among evaluable patients at day 45 (40 of 49 evaluable patients). No patient lost a previously achieved response. There were no cases of de novo grade 3 or 4 graft-versus-host disease, graft failure, or infusion-related toxicities. BKV-CTLs were identified in patient blood samples up to 3 months postinfusion and their in vivo expansion predicted for clinical response. A matched-pair analysis revealed that, compared with standard of care, after accounting for prognostic covariate effects, treatment with BKV-CTLs resulted in higher probabilities of response at all follow-up timepoints as well as significantly lower transfusion requirement.Off-the-shelf BKV-CTLs are a safe and effective therapy for the management of patients with BKV-HC after AHSCT.


View the full article @ Journal of clinical oncology : official journal of the American Society of Clinical Oncology


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Authors: Amanda Olson, Ruitao Lin, David Marin, Hind Rafei, Mustafa H Bdaiwi, Peter F Thall, Rafet Basar, Ala Abudayyeh, Pinaki Banerjee, Fleur M Aung, Indresh Kaur, Glorette Abueg, Sheetal Rao, Roy Chemaly, Victor Mulanovich, Gheath Al-Atrash, Amin M Alousi, Borje S Andersson, Paolo Anderlini, Qaiser Bashir, Karla M Castro, May Daher, Isabel M Galvan, Chitra Hosing, Jin S Im, Roy B Jones, Partow Kebriaei, Issa Khouri, Rohtesh Mehta, Jeffrey Molldrem, Yago Nieto, Betul Oran, Uday Popat, Muzaffar Qazilbash, Gabriela Rondon, Neeraj Saini, Bryan Spencer, Samer Srour, Dominique Washington, Melissa Barnett, Richard E Champlin, Elizabeth J Shpall, Katayoun Rezvani

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