Platelet-rich plasma (PRP) may be a useful treatment for androgenetic alopecia (AGA), although objective studies are needed.To determine whether PRP injections improve female AGA.Prospective, randomized controlled trial of 30 females diagnosed with AGA. Patients received subdermal scalp injections of Eclipse system PRP or placebo saline at weeks 0, 4 and 8. Outcome measures were changes in hair density (hair/cm2), hair caliber (mm), and blinded global photographic assessment (improved or not improved) at week 24.Blinded global photographic assessment indicated that 57% of PRP patients vs. 7% of saline patients improved at week 24 from baseline (p<0.01). Compared to baseline, there was improvement in mean density in the PRP group vs. the placebo group at week 8 (+71.1 vs. -26.7 hairs/cm2, p<0.01) and week 24 (+105.9 vs. -52.4 hairs/cm2, p<0.01). Compared to baseline, there was improvement in mean caliber in the PRP group vs. the placebo group at week 8 (+0.0043 vs. -0.0034 mm, p<0.01) and week 24 (+0.0053 vs. -0.0060 mm, p<0.01). Adverse effects included headache, scalp tightness, swelling, redness, and post-injection bleeding.Two patients lost to follow-up.PRP with the Eclipse system is a safe and effective intervention for female AGA.