The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment.

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Authors: Thai Hoa Tran, Jonathan V Nguyen, Adrian Stecula, Jon Akutagawa, Anthony V Moorman, Benjamin S Braun, Andrej Sali, Charles G Mullighan, Neil P Shah, Yunfeng Dai, Meenakshi Devidas, Kathryn G Roberts, Catherine C Smith, Mignon L Loh