Addressing risk factors of delayed melanoma detection minimizes disparities in outcome.Elucidate the significance of marital status in melanoma outcomes across anatomic sites.Retrospective cohort study of 73,558 patients from the Surveillance, Epidemiology and End Results (SEER) program and 2,992 patients at Johns Hopkins University. Patients were stratified by marital status, anatomic site, age, and sex. Endpoints were prevalence of advanced melanoma (stages III-IV) and survival.In the SEER cohort, single patients were more likely to present in stages III-IV than married ones among both males (Prevalence ratio PR 1.45, 95% CI 1.37-1.53) and females (PR 1.28 95% CI 1.18-1.39). This trend was consistent across all anatomic sites and in all age groups, particularly 18-68 years old. Overall and cancer-specific survival was shorter in unmarried patients. Similarly, at Johns Hopkins, single patients had increased prevalence of advanced melanoma (PR 1.54, 95% CI 1.21-1.94), and experienced shorter overall survival (Hazard ratio HR 1.51, 95% CI 1.15-1.99).Anatomic sites were not very specific; retrospective study.Unmarried patients, especially males and those under 68, are diagnosed at more advanced stages even in readily visible sites like the face. They also experience worse survival independent of stage.