Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated with Type 2 Myocardial Infarction.

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Little is known about the association between acute prevalent conditions in patients with type 2 Myocardial Infarction (T2MI) and clinical outcomes, particularly between sexes. Using the Nationwide Inpatient Sample (2015-2017), we examined outcomes of T2MI in patients stratified by prevalent associated conditions (renal failure, decompensated heart failure, infection, acute respiratory failure, cardiac arrhythmias, bleeding) and sex. Multivariable logistic regression was performed to assess the odds ratios (OR) of in-hospital all-cause mortality in each of the study groups. A total of 38,715 T2MI patients were included in the analysis, of which 47.9% (n=18,540) were females. Renal failure was the most common prevalent condition in both sexes (males: 60%; females: 52.6%). Acute respiratory failure was associated with the greatest odds of mortality (OR 5.46, 95% confidence interval (CI) 5.02-5.94) when compared to other conditions: renal failure (OR 2.20 95% CI 2.01-2.40), infections (OR 2.96 95% CI 2.72-3.21), major bleeding (OR 1.71 95% CI 1.52-1.93), arrhythmias (OR 1.30 95% CI 1.19-1.43) and decompensated heart failure (OR 0.71, 95% CI 0.65-0.77). However, there was no difference in mortality between sexes for all acute conditions except renal failure (females OR: 1.02, 95% CI 1.02-1.02, p=0.011). In conclusion, in-hospital mortality after T2MI differs according to the underlying acute condition, with acute respiratory failure being associated with the highest rate of mortality. No significant differences in mortality were observed between sexes amongst all prevalent acute conditions, with the exception of renal failure which was marginally higher in females.


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Authors: Mohamed O Mohamed, Tahmeed Contractor, Dmitry Abramov, Purvi Parwani, Erin D Michos, David Fischman, M Chadi Alraies, Rodrigo Bagur, Mamas A Mamas

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