The exact mechanisms that trigger the onset of puberty are not well known. Adipomyokines are postulated to stimulate the central neural network. In the present study, we investigated irisin levels in girls with central precocious puberty (CPP), slowly progressing precocious puberty (SPPP) or premature thelarche (PT), and also prepubertal girls and determined if this adipomyokine could be used as a marker in this context.A total of 94 girls including 33 with CPP, 31 with precocious puberty (PP) variants (SPPP or PT), and 30 healthy controls were enrolled to the study. The mean irisin levels were compared between the groups. The bivariate correlations of irisin levels with clinical and laboratory parameters were assessed. Multivariate linear regression analysis was performed to determine independent predictive factors of irisin levels.Irisin levels were higher in the CPP group compared with the other groups (CPP group: 723.25±62.35 ng/mL, PP variants group: 529.60±39.66 ng/mL, and control group: 325.03±27.53 ng/mL) (p<0.001). Irisin levels were positively correlated with body mass index standard deviation scores (SDS); height-SDS; weight-SDS; bone age; uterus long axis; size of the ovary; baseline follicle stimulating hormone and luteinizing hormone (LH); and peak LH levels. Multivariate linear regression analysis revealed that irisin levels had the strongest correlation with peak LH. The other independent predictive factor of irisin levels was BMI-SDS.The mean irisin levels were higher in patients with CPP compared with other groups. The results of this study imply that increased irisin levels may be used as a marker of CPP provided that these findings are confirmed in larger prospective studies.