Transition from pediatric to adult care is a critical component of healthcare for children with chronic needs. The characteristics of epidermolysis bullosa (EB) demand higher than average levels of provider support. There is consensus among health care professionals regarding the importance of transition, however, there is a scarcity of practical information regarding models for patients with EB.Review transition of care (TOC) programs in varying specialties. Highlight practical considerations to facilitate the development of programs for patients with EB and other complex dermatologic conditions.Articles identified via MEDLINE and EMBASE health literature database and screened for relevance to TOC.Various models for transition exist. A well-executed formal transition program, early introduction, interdisciplinary collaboration and psychosocial support were themes associated with successful outcomes.TOC programs that have not been described in the literature are not reflected in this review.Patients with EB have unique needs that affect transition and span expertise across traditional boundaries such as dependency on others for daily skin care, failure to thrive, and risk of squamous cell carcinoma. Given the rarity of the disease, patients with EB will benefit from collaborative efforts to develop programs to optimize successful transition.