Psoriasis impacts the health and psychosocial functioning of patients, conferring a significant economic burden on healthcare systems. There remain unmet needs in psoriasis care, which if addressed by research, could improve clinical outcomes.Between July 2017 and November 2018 we conducted a Priority Setting Partnership for psoriasis (PsPSP). We invited those with lived-experience of psoriasis and healthcare professionals to: i) identify unmet needs; and ii) prioritise the order these should be addressed by research. We collaborated with the Psoriasis Association and utilised methodology established by the James Lind Alliance, who pioneer the joint setting of research priorities by patients and clinicians worldwide.In our harvesting survey (Survey 1), 2133 questions were submitted by 805 individuals. Submissions that had not been answered by research (true uncertainties) were supplemented with "evidence gaps" from systematic reviews/guidelines published in the last five years and refined to produce 55 indicative questions. Voting in Survey 2, by 1154 individuals, enabled a shortlist of questions, which were prioritised during the Final Workshop to produce a "Top 20" list of research questions. Submissions on "Health Service Delivery" (5.8% of the total submissions), which were analysed separately, described a blueprint for psoriasis care.The PsPSP will inform the translational research agenda, ensuring that future research is relevant for the needs of people with psoriasis and those who manage the disease. Submissions on "Health Service Delivery" describe a model of holistic, patient-focused care providing high quality, effective management for patients with psoriasis.