We evaluated sequelae of disease and therapy in adolescents with chronic endocrinopathies using a medical and psychological work-up to record Health related Quality of Life (HRQoL), near final heights (NFH), and body compositions during the transition period from paediatric to adult care.NFH, weight, body mass index (BMI), grip strength (GS), hip and waist circumference (HC; WC), skin folds (SF), and HRQoL T-scores by KIDSCREEN and DISABKIDS were assessed in 134 patients (70 female, 64 male) from May 2010 to March 2016 diagnosed with congenital adrenal hyperplasia (CAH; n=22), multiple pituitary hormone deficiencies (MPHD; n=17), growth hormone deficiency (GHD; n=37), Turner syndrome (TS; n=27), SGA-short stature (SGA; n=20), Klinefelter syndrome (KS; n=11).Median HRQoL T-scores for KIDSCREEN (50.6-56.5) and DISABKIDS (52.7-58.9) ranged within references with considerable variations but without significant deficit in any diagnosis. Median corrected height SDS (CoH-SDS: NFH SDS - TH (Target Height) SDS) was >-1, except in KS (SDS +1.3) and in TS (SDS - 1.9; p<0.0001) without correlations to HRQoL. Median BMI was below 25 kg/m2 in all patients except MPHD (26.5 kg/m2 ; SDS 1.5; p=0.006). BMI correlated negatively in CAH females with self-perception (rs = -0.64, p=0.0338), physical well-being (rs= -0.8; p=0.0086), social exclusion rs= -0.65; p=0.031) and emotions (rs = -0.7; p=0.0169).HRQoL and body compositions were similar to those of healthy adolescents. Lower scores in HRQoL dimensions as self-perception, physically well-being, social exclusion, and emotions were detected and correlated negatively with BMI. Treatment strategies and psychological support should consider HRQoL and adapted in specific treatment guidelines.