Psychometrics of HRQoL questionnaires in bronchiectasis: A systematic review and meta-analysis.

Like Comment
Understanding the psychometric properties of health related quality of life (HRQoL) questionnaires can help inform selection in clinical trials.To assess the psychometric properties of HRQoL questionnaires in bronchiectasis.A literature search was conducted. HRQoL questionnaires were assessed for psychometric properties (reliability, validity, minimal clinically important difference (MCID), floor/ceiling effects). Meta-analyses assessed the associations of HRQoL with clinical measures and responsiveness of HRQoL in clinical trials.166 studies and 12 HRQoL questionnaires were included. The BHQ, LCQ, CAT and SF-36 had good internal consistency in all domains reported (Cronbach's α≥0.7) across all studies and the QoL-B, SGRQ, CRDQ and SOLQ had good internal consistency in all domains in the majority of (but not all) studies. The BHQ, SGRQ, LCQ and CAT had good test-retest reliability in all domains reported ((intraclass correlation coefficient) ICC ≥0.7) across all studies and the QoL-B, CRDQ and SOLQ had good test-retest reliability in all domains in the majority of (but not all) studies. HRQoL questionnaires were able to discriminate between demographics, important markers of clinical status, disease severity, exacerbations and bacteriology. For HRQoL responsiveness, there was a difference between the treatment and placebo effect.SGRQ was the most widely used HRQoL questionnaire in bronchiectasis studies and it had good psychometric properties, however good psychometric data are growing on bronchiectasis specific HRQoL questionnaires, QoL-B and BHQ. Future studies should focus on the medium-long term test-retest reliability, responsiveness and MCID in these HRQoL questionnaires which show potential in bronchiectasis.


View the full article @ The European respiratory journal


Get PDF with LibKey
Authors: Rebecca H McLeese, Arietta Spinou, Zina Alfahl, Michail Tsagris, J Stuart Elborn, James D Chalmers, Anthony De Soyza, Michael R Loebinger, Surinder S Birring, Konstantinos C Fragkos, Robert Wilson, Katherine O'Neill, Judy M Bradley

ClinOwl

The wider, wiser view for healthcare professionals. ClinOwl signposts the latest clinical content from over 100 leading medical journals.
6147 Contributions
2 Followers
0 Following