Prospective Observational Trial of Low-Dose Skin Electron Beam Therapy in Mycosis Fungoides Using a Rotational Technique.

Low dose total skin electron beam therapy (TSEBT) provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma (CTCL). We prospectively assessed the durability of response and quality of life (QOL) for patients receiving low dose TSEBT utilizing a novel rotational technique and dosing regimen.Patients with completed baseline Skindex-29 QOL surveys and had baseline modified severity-weighted assessment tool (mSWAT) recorded. Patients received 12 Gy in 12 fractions using a dual field rotational technique. The primary outcome was overall response rate (ORR) with the secondary outcomes being time to treatment response, duration of clinical benefit, and QOL change.We enrolled 20 patients and recorded an ORR of 90%. The median time to treatment response was 6.5 weeks. The baseline mSWAT score was 55.6 and it declined to a median of 2.2 at last follow-up (p<0.001). The median duration of clinical benefit was 21 months. There was a decline in the Skindex-29 total score and every subdomain when comparing each follow-up visit (p=0.004).This prospective study demonstrates a very high ORR and improvement in skin-related QOL. Low dose rotational TSEBT can be implemented routinely in clinical practice.

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