Screening and appropriate management of prediabetes might contribute to the primary and secondary prevention of cardiovascular disease (CVD), according to researchers behind a new meta‑analysis* published in the BMJ. They found that prediabetes was associated with an increased risk of all-cause mortality and CVD in the general population, as well as in patients with atherosclerotic CVD.
The research team, led from Foshan, China, wanted to clarity whether or not prediabetes (intermediate hyperglycaemia or non-diabetic hyperglycaemia) was associated with an increased risk of all-cause mortality and CVD in the general population and in patients with a history of atherosclerotic CVD; and also whether different definitions of prediabetes were related to different prognoses.
They analysed data from 129 cohort studies or post hoc analysis of clinical trials, with a total of 10,069,955 participants, that had investigated adjusted relative risks, odds ratios, or hazard ratios of all-cause mortality or CVD for prediabetes compared with normoglycaemia.
*Cai X, Zhang Y, Li M, et al. Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis. BMJ 2020; 370: m2297. DOI:10.1136/bmj.m2297