Metabolic Syndrome and its Factors are Associated with Non-Calcified Coronary Plaque Burden in Psoriasis: An Observational Cohort Study.

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Psoriasis is associated with a heightened risk of cardiovascular disease (CVD) and higher prevalence of metabolic syndrome (MetSyn) and its individual components.Investigate the impact of MetSyn and its components on early coronary artery disease assessed as non-calcified coronary burden (NCB) by coronary computed tomography angiography (CCTA) in psoriasis.This cross-sectional study consisted of 260 participants with psoriasis and CCTA results. MetSyn was defined according to the harmonized International Diabetes Federation criteria.Of the 260 participants, 80 had MetSyn (31%). The MetSyn group had a higher burden of cardiometabolic disease, systemic inflammation, NCB, and high-risk plaque. After adjusting for Framingham risk score, lipid-lowering therapy, and biologic use, MetSyn (β=0.31; p


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