Lymphomatoid papulosis types D and E: a multicenter series of the French Cutaneous Lymphomas Study Group.

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Lymphomatoid papulosis (LyP) type D (LyP D) and type E (LyP E) have recently been described in small series of cases or isolated case reports.To further describe the clinical and histologic features of LyP D and E based on a retrospective multicenter study.The clinical and histopathological features of 29 patients with an initial diagnosis of LyP D or LyP E were retrospectively assessed using standardized forms.After exclusion of 5 cases, 24 patients were included (14 LyP D, 10 LyP E). The median follow-up was 2.5 years (1 month-13 years). LyP D consisted in multiple recurrent self-regressing small papules that developed central erosion or necrosis; whereas LyP E were papulonodular lesions that rapidly evolved into >1cm necrotic eschar-like lesions. Epidermal changes were more frequent in LyP D, dermal infiltrates were deeper in LyP E, anaplastic cytology was rare and the DUSP22 rearrangement was never observed. Two patients (8%) had an associated cutaneous lymphoma.LyP D and E have distinct clinical findings and may be associated with other cutaneous lymphomas.


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Authors: C Bergqvist, M Beylot-Barry, C Ram-Wolff, B Vergier, M Bagot, M Battistella, S Dalle, B Balme, J P Merlio, F Durupt, Y Le Corre, N Bonnet, P Le Bozec, F Skowron, I Vivard-Wallee, O Dereure, F Brunet-Possenti, S Ingen-Housz-Oro, N Ortonne

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