Limited sensitivity and specificity of ACR/EULAR-2019 classification criteria for SLE in JSLE? - Observations from the UK JSLE Cohort Study.

This study aimed to test the performance of the "new" American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) criteria, that include anti-nuclear antibodies (ANA) positivity as entry criterion, in juvenile-onset systemic lupus erythematosus (jSLE).Performance of the ACR/EULAR-2019 criteria were compared with Systemic Lupus International Collaborating Clinics (SLICC-2012), using data from children and young people (CYP) in the UK JSLE Cohort Study (n = 482), with the ACR-1997 criteria used as reference standard. An "unselected" cohort of CYP positive for ANA (n = 129) was used to calculate positive/negative predictive values of the criteria.At both first and last visit, the number of patients fulfilling the different classification criteria varied significantly (p 

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Authors: Eve M D Smith, Sajida Rasul, Coziana Ciurtin, Eslam Al-Abadi, Kate Armon, Kathryn Bailey, Mary Brennan, Janet Gardner-Medwin, Kirsty Haslam, Daniel P Hawley, Steven Lane, Alice Leahy, Valentina Leone, Gulshan Malik, Devesh Mewar, Robert Moots, Clarissa Pilkington, Athimalaipet V Ramanan, Satyapal Rangaraj, Annie Ratcliffe, Phil Riley, Ethan Sen, Arani Sridhar, Nick Wilkinson, Michael W Beresford, Liza J McCann, Christian M Hedrich