Reduction in unwanted facial and body hair is an important goal in the process of sex reassignment. Laser treatment is a well-established, effective, popular and safe method of reducing unwanted hair growth. In the UK a limited number of laser treatment and electrolysis sessions are publically funded for those undergoing sex reassignment. To date published evidence on efficacy and adverse effects focuses on treatment of women and men not undergoing sex reassignment. Data was collected prospectively from 2015 to 2020 at a UK regional laser centre. Patients were included if they were transgender women aged over 16 years old and seeking laser treatment for unwanted hair at any body site. The study demonstrated significant reductions in hair growth and significant patient satisfaction, with no adverse incidents. Laser treatment is a safe and effective method of managing unwanted hair growth in the transgender transfeminine population.