Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men with Central Obesity.

Prolonged sitting elevates postprandial metabolic markers, resulting in increased risks of cardiovascular diseases and type-2 diabetes. Interrupting prolonged sitting may reduce these risks. However, more information is needed to understand the patterns of interrupting prolonged sitting to obtain metabolic health benefits.The study examined the effects of interrupting prolonged periods of sitting with different intensities and durations of walking with an equivalent energy expenditure on postprandial metabolic responses in young Chinese men with central obesity.Randomized crossover experimental trial.Participants underwent three 6-h experiments with a 7-day washout period between each experiment: prolonged sitting (SIT), 3 min of light-intensity walking every 30 min (3 min), and 1.5 min of moderate-intensity walking every 30 min (1.5 min).Baseline (fasting) and 6-h postprandial metabolic glucose and lipid levels were analyzed among 18 young Chinese men with central obesity.Generalized estimating equations (adjusted for the potential confounders explaining residual outcome variance (body mass index (BMI) and age), trial order, preprandial values, and lead-in activity) were used, and the incremental areas under the curve (iAUC) of each outcome were compared between prolonged sitting and interrupted prolonged sitting conditions.Compared with SIT, both interrupting prolonged sitting conditions reduced the iAUCs for glucose (p < 0.05) but not insulin, C-peptide, triglycerides, or nonesterified fatty acids.Both conditions of interrupted prolonged sitting reduced postprandial glucose concentrations in young Chinese men with central obesity when the energy expenditure was equivalent.

View the full article @ The Journal of clinical endocrinology and metabolism

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