Hand eczema (HE) is frequently colonized with Staphylococcus aureus (S. aureus); however, its role in the pathogenesis of HE is poorly understood.To investigate temporal variation of S. aureus sub-types, i.e. Clonal Complex (CC) types on hands and relate to nose colonization and severity in a cohort of HE-patients.Prospectively identify S. aureus from the hands and nose of 50 adult HE-patients and 50 controls at five visits over three weeks.S. aureus was identified on the hands in 23 patients (46%) at two or more visits, and in one control once. Of colonized HE-patients, 78% had the same S. aureus CC-type over time. Twenty-one patients had the same S. aureus CC-type on the hands and in the nose. Persistent colonization was strongly related to increased disease severity.The relatively small S. aureus culture-positive population.Temporal stability of S. aureus CC-type and high occurrence of identical sub-type on the hands and in the nose imply S. aureus colonization in HE to be of a more permanent nature. Together with the finding that persistent colonization and HE severity are clearly related, our results indicate that S. aureus may contribute to the perpetuating course of HE.
Line B Nørreslet, Sofie M Edslev, Maja-Lisa Clausen, Esben M Flachs, Niels E Ebbehøj, Paal S Andersen, Tove Agner