Functional Abdominal Pain Disorders and Constipation in Children on Gluten-Free Diet.

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We studied the prevalence of functional abdominal pain disorders (FAPDs) and functional constipation (FC) in a large prospective cohort of children with coeliac disease on strict gluten free diet (GFD).We performed a prospective cohort study, from 2016 through 2018, in a tertiary care center in Italy, of 417 patients (37% male; mean age, 13.7 years) with a diagnosis of coeliac disease (ESPGHAN criteria) who had been on a strict GFD for more than 1 year and had negative results from serologic tests after being on the GFD. Parents and children (older than 10 years) were asked to fill in a questionnaire on paediatric gastrointestinal symptoms, according Rome IV criteria. Patients' closest siblings (or cousins) who had negative results from serologic test for coeliac disease were used as controls (n=373; 39% male; mean age, 13.5 years).We found a higher prevalence of FAPDs among patients with coeliac disease (11.5%) than controls (6.7%) (P<0.05); the relative risk (RR) was 1.8 (95% CI, 1.1-3.0). Irritable bowel syndrome (IBS) and functional constipation (FC) defined by the Rome IV criteria, were more prevalent in patients with coeliac disease (7.2% for IBS and 19.9% for FC) than controls (3.2% for IBS and 10.5% for FC) (P


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