Gene-exercise interaction on cross-sectional BMI has been extensively studied and is well established. However, gene-exercise interaction on changes in body weight/BMI remains controversial.To examine the interaction between the FTO obesity variant and regular exercise on changes in body weight/BMI.Taiwan Biobank participants aged 30 to 70 years (N = 20,906) were examined at both baseline and follow-up visit (mean follow-up duration: 3.7 years).The interaction between the FTO obesity variant rs1421085 and regular exercise habit (no exercise, ≤20METs/week exercise, >20METs/week exercise) on changes in body weight/BMI.Individuals with the risk allele of rs1421085 gained more weight and increased BMI than those without the risk allele if they do not exercise. In contrast, individuals with the risk allele gained less weight and BMI if they exercise regularly, indicating an interaction between rs1421085 and regular exercise habit (P = 0.030 for Δbody weight and P = 0.034 for ΔBMI). The effect of exercise on maintaining body weight was larger in those with the risk allele of rs1421085. When we focused on individuals without regular exercise at baseline, individuals with the risk allele again tended to lose more weight compared to those with a non-risk allele if they had acquired an exercise habit by the follow-up visit.The beneficial effect of exercise is greater in individuals genetically prone to obesity due to the interaction between the FTO obesity variant rs1421085 and regular exercise on changes in body weight and BMI.
Yuta Hiraike, Chao-Tung Yang, Wei-Ju Liu, Tomohide Yamada, Chia-Lin Lee