Eyelid Dermatitis in Patients Referred for Patch Testing: Retrospective Analysis of North American Contact Dermatitis Group Data, 1994 - 2016.

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Eyelid dermatitis is a common dermatologic complaint.To characterize patients with eyelid dermatitis.Retrospective analysis (1994 - 2016) of North American Contact Dermatitis Group data.Of 50,795 patients, 2,332 (4.6%) had eyelid dermatitis only (E-only), while 1,623 (3.2%) also had dermatitis of the head/neck (E+HN). When compared to patients without eyelid involvement (NoE, n=26,130), E-only and E+HN groups were significantly more likely to be female, Caucasian, aged >40, and have a history of hay fever and/or atopic dermatitis (p-values<0.01). Final primary diagnoses included allergic contact dermatitis (E-only: 43.4%, E+HN: 53.5%), irritant contact dermatitis (E-only: 17.0%, E+HN: 9.8%), and atopic dermatitis (E-only: 13.1%, E+HN: 13.8%). Top 5 currently relevant allergens included nickel sulfate (E-only: 18.6%, E+HN: 22.5%), fragrance mix I (E-only: 16.5%, E+HN: 18.3%), methylisothiazolinone (E-only: 16.5%, E+HN: 17.7%), gold sodium thiosulfate (E-only: 14.7%, E+HN: 11.4%), and balsam of Peru (E-only: 11.9%, E+HN: 12.6%). Both eyelid groups were significantly more likely to react to gold sodium thiosulfate, carmine, shellac, dimethylaminopropylamine, oleamidopropyl dimethylamine, and thimerosal (p-values<0.05) as compared to the NoE group.Lack of specific distribution patterns of eyelid dermatitis and no long-term follow-up data.Patch testing remains a critical tool in evaluating patients with eyelid dermatitis.

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