Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age.This study was designed to evaluate effects of lifestyle modifications and synbiotic supplementation on PCOS.A randomized (1:1) double-blind, placebo-controlled trial.Academic hospital.Overweight and obese women with PCOS were identified according to the Rotterdam criteria. Evaluations were performed at baseline and repeated after 3 months of treatment.Lifestyle modifications in combination with synbiotic supplementation or placebo.Change in BMI and testosterone level.In the Placebo Group, a 5% decrease in BMI was accompanied by significant decreases of the waist, hip, and thigh circumferences. The Synbiotic Group experienced an 8% decrease in BMI, which was significantly greater than that in the Control Group (P=0.03) and was accompanied by decreases in the waist, hip, and thigh circumferences. Testosterone did not decrease significantly in the Placebo Group (decrease of 6%), while in the Synbiotic Group it decreased by 32% (P<0.0001). The decrease of testosterone was significantly greater in the Synbiotic Group than in the Placebo Group (P=0.016).Synbiotic supplementation potentiated effects of lifestyle modifications on weight loss and led to significant reduction of serum testosterone.
Izabela Chudzicka-Strugała, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J Duleba