Diagnosing Atopic Dermatitis in Infancy Using Established Diagnostic Criteria: A Cohort Study.

Like Comment
Diagnosing atopic dermatitis (AD) in infants is challenging.To determine incidence and persistence of eczema and AD in infants using the UK Working Party (UKWP) and Hanifin&Rajka's (H&R) criteria.A cohort of 1834 infants were examined clinically at 3, 6 and 12 months of age. Eczema was defined as eczematous lesions excluding differential diagnosis to AD. Atopic dermatitis was diagnosed by UKWP (3, 6 and 12 months) and H&R (12 months) criteria. Logistic regression models were used to assess the relationship between AD and eczema.Eczema was observed in 628/1834 (34%) infants; 240, 359 and 329 at 3, 6 and 12 months, respectively, with AD diagnosed in 212 (34%) of infants with any eczema, and in 64/78 (82%) infants with eczema at all three visits. Odds for AD were lower with first presentation of eczema at 6 (OR: .33; 95% CI: .22 - .48) or 12 months (OR: .49; .32 - .74) compared to three months, and higher in infants with eczema at three (OR: 23.1; 95% CI: 12.3-43.6) or two (6.5; 4.3-9.9) visits compared to one visit only. At 12 months, 156/329 (47%) fulfilled the UKWP and/or H&R criteria; 27 (8%) the UKWP criteria only and 65 (20%) the H&R criteria only in whom 44/129 (34%) did not meet the itch criterion.The UKWP and H&R criteria for AD used in combination and at multiple time points may be useful in clinical research, but may have limited value in most other clinical settings.


View the full article @ The British journal of dermatology


Get PDF with LibKey

ClinOwl

The wider, wiser view for healthcare professionals. ClinOwl signposts the latest clinical content from over 100 leading medical journals.
5027 Contributions
2 Followers
0 Following

No comments yet.