Development and Validation of Three Preliminary MRI Sacroiliac Joint Composite Structural Damage Scores in a 5-year Longitudinal Axial Spondyloarthritis Study.

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In axial spondyloarthritis (axSpA), sacroiliac joint (SIJ) erosion is often followed by fat metaplasia in an erosion cavity (backfill), and subsequently ankylosis. We aimed to combine Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ Structural score for Erosion, Backfill and Ankylosis into 3 versions of a novel preliminary Composite axSpA MRI SIJ Structural Damage Score (CSDS) and test these.Thirty-three axSpA patients followed for 5 years after initiation of tumor necrosis factor inhibitor had MRI of SIJs at baseline, and yearly thereafter. Three versions of CSDSs were calculated based on different weightings of erosion, backfill and ankylosis: Equal weighting: CSDSequal=(erosion x0.5)+backfill+ankylosis; Advanced stages weighting more: CSDSstepwise=(erosion x1)+(backfill x4)+(ankylosis x6); Advanced stages overruling earlier stages ("hierarchical") with "

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Authors: Marie Wetterslev, Mikkel Østergaard, Inge Juul Sørensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Lars Juul, Gorm Thamsborg, Ole Rintek Madsen, Jakob Møllenbach Møller, Susanne Juhl Pedersen


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