Current knowledge and management of portal vein thrombosis in cirrhosis.

Portal vein thrombosis (PVT) is a complication of cirrhosis that is being increasingly recognized and increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipient is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on patient and thrombus characteristics. This manuscript reviews current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis.

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Authors: Marco Senzolo, Guadalupe Garcia-Tsao, Juan Carlos García-Pagán