CCL20 in Psoriasis: A Potential Biomarker of Disease Severity, Inflammation, and Impaired Vascular Health.

Like Comment
Psoriasis is associated with increased cardiovascular risk that is not captured by traditional pro-inflammatory biomarkers.To investigate the relationship between psoriasis area and severity index (PASI), circulating pro-inflammatory biomarkers, and vascular health in psoriasis.In psoriasis and age, sex-matched controls, 273 proteins were analyzed utilizing the OLINK platform, while vascular endothelial inflammation and health was measured via direct transcriptomic analysis of brachial vein endothelial cells.In psoriasis, CCL20, IL-6, and IL-17A were the top three circulating pro-inflammatory cytokines. Vascular endothelial inflammation correlated with CCL20 (r=0.55, p<0.001) and less so with IL-6 (r=0.36, p=0.04) and IL-17A (r=0.29, p=0.12). After adjustment for potential confounders the association between CCL20 and vascular endothelial inflammation remained significant (β =1.71, p=0.02). In nested models, CCL20 added value (χ2 = 79.22, p<0.001) to a model already incorporating PASI, Framingham Risk, hs-CRP, Il-17A and IL-6 (χ2 = 48.18, p<0.001) in predicting vascular endothelial inflammation.Our study was observational and does not allow for causal inference in the relationship between CCL20 and cardiovascular risk.We demonstrate that CCL20 expression has a strong association with vascular endothelial inflammation, reflects systemic inflammation, and may serve as a potential biomarker of impaired vascular health in psoriasis.


View the full article @ Journal of the American Academy of Dermatology


Get PDF with LibKey

ClinOwl

The wider, wiser view for healthcare professionals. ClinOwl signposts the latest clinical content from over 100 leading medical journals.
5803 Contributions
2 Followers
0 Following