Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency.

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Bronchiectasis is a well-recognised complication of primary antibody deficiency (PAD) syndromes. Previous data suggest that mortality in common variable immune deficiency (CVID) is not associated with isolated bronchiectasis. A retrospective analysis of patients with CVID and specific antibody deficiency in two tertiary referral centres with lung disease was conducted. Severity of bronchiectasis at presentation was associated with mortality. Lower FEV1, colonisation with Pseudomonas aeruginosa and a diagnosis of COPD were also associated with mortality. Bronchiectasis is an important driver of mortality in patients with PAD syndromes.


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Authors: Jimstan Periselneris, Silke Schelenz, Michael Loebinger, Patricia Macedo, Zoe Adhya, Darius Armstrong-James, W Peter Kelleher

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