Bone mineral density at extremely low weight in patients with anorexia nervosa.

Low bone mineral density (BMD) is a frequent and invalidating consequence of chronic undernourishment in patients with Anorexia Nervosa (AN). The aim of this study was to assess prevalence and clinic-biological correlates of low BMD and fractures in extremely undernourished inpatients with AN.Retrospective cohort study.This study included 97 extremely malnourished female inpatients with AN consecutively admitted over 2 years. Clinical-biological variables, history of fractures, and BMD by dual energy X-ray absorptiometry (DXA) were examined to find predictors of low BMD and fractures. Prevalence of low BMD was of 51% for lumbar spine and 38% for femoral neck. Z-scores were lower at lumbar spine (-2.2±1.2 SD) than at femoral neck (-1.9±0.9 SD) (p


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Authors: Pauline Bemer, Laura Di Lodovico, Ohanyan Haykanush, Hélène Théodon, Karine Briot, Robert Carlier, Marika Dicembre, Maéva Duquesnoy, Jean-Claude Melchior, Mouna Hanachi