Azathioprine hypersensitivity syndrome. Report of two cases with cutaneous manifestations.

Azathioprine is an immunosuppressant drug used in many dermatological and non-dermatological pathologies. Azathioprine hypersensitivity syndrome is a rare idiosyncratic reaction no related to dose or thiopurine methyltransferase activity. Up to half of the cases can present with variable cutaneous manifestations besides fever, malaise and other systemic symptoms. It is important to be aware of this syndrome, as maintenance or rechallenge of the drug can led to multiorgan failure and cardiovascular collapse.

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Authors: C Moya-Martínez, L Núñez-Hipólito, S Barrio-González, C Santonja, M J Velasco, I Lorda Sánchez, M C Fariña-Sabaris, L Requena