Association of Single Nucleotide Polymorphisms in the CXCR1, CXCR2 and CXCL5 with the Behçet's Disease in Denizli Province of Turkey.

Behçet's disease (BD) is associated with the immune system, especially neutrophilic activity. The CXCR1, CXCR2 and CXCL5 mediate the activation and migration of the neutrophils.The aim of our study was to investigate the CXCR1, CXCR2 and CXCL5 gene polymorphisms in association with BD.We studied four CXCR1 polymorphic sites, rs16858811, rs9282752, rs16858809 and rs16858808, three CXCR2 polymorphic sites, rs2230054, rs1126579 and rs1126580, and CXCL5 rs352046 polymorphic site in 87 BD patients and 111 healthy controls (HCs). We used PCR-RFLP based approach for genotyping.The CXCR2 rs2230054 TT genotype and the CXCL5 rs352046 could be one of the possible genetic factors responsible for BD. The results show that there is no association between the development of BD and the CXCR1 polymorphisms and other CXCR2 SNPs. Together with these results, our haplotype analysis results indicate that the haplotypes of the CXCR2 and CXCR1-CXCR2 polymorphic loci are different in the BD and HCs.Our study suggests that the polymorphisms of CXCR1, CXCR2 and CXCL5 may affect the susceptibility to BD and increase the risk of developing disease. It is necessary to study these loci in a larger scale and from different geographical areas around the world populations to be able to understand the real possible genetic background for the development in BD pathogenesis.

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Authors: S Arikan, A Atalay, O Öztürk, Ş Duygulu, E Ö Atalay