Association between Plasma Aldosterone, and Markers of Tubular and Glomerular Damage in Primary Aldosteronism.

Although renal impairments are observed in patients with primary aldosteronism (PA), the association between plasma aldosterone concentration (PAC) and specific structural kidney damage remains unknown. Thus, we analyzed the association between PAC, and markers of glomerular and tubular damage.This was a retrospective cross-sectional study of 96 PA patients, in which we analyzed the association between PAC and markers of kidney damage, including urinary albumin-creatinine ratio (ACR) for glomerular damage, and urinary liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG), and β2-microglobulin (β2-MG) for tubular damage. In addition, we evaluated the association between PAC and N-terminal pro-brain natriuretic peptide (NT-proBNP) as a marker for body fluid volume.Urinary ACR, L-FABP, NAG, β2-MG, and NT-proBNP significantly correlated with PAC. PAC (<415 pmol/L, 415-550, 550-740, 740

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