Antiphospholipid Patterns Predict Risk of Thrombosis in Systemic Lupus Erythematosus.

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We evaluated which antiphospholipid antibody combinations increase the risk of future thrombosis in patients with SLE.This prospective cohort study consisted of SLE patients who had been tested for all seven antiphospholipid antibodies [lupus anticoagulant (LAC), anticardiolipin (aCL) isotypes IgM, IgG, IgA, and anti-β2-glycoprotein I isotypes IgM, IgG, IgA]. Pooled logistic regression was used to assess the relationship between antiphospholipid antibodies and thrombosis.There were 821 SLE patients with a total of 75048 person-months of follow up. During the follow-up we observed 88 incident cases of thrombosis: 48 patients with arterial, 37 with venous and three with both arterial and venous thrombosis. In individual models; LAC was the most predictive of any [3.56 (2.01, 6.30) p 


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