Animal Models for Liver Disease - A Practical Approach for Translational Research.

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Animal models are crucial not only for the understanding of human pathogenesis in order to identify therapeutic targets, but also to test novel drugs. In the current review, we provide a comprehensive summary of mostly used experimental models of chronic liver disease, starting from early stages of fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis and alcoholic liver disease, advanced cirrhosis and end-stage primary liver cancer. We focused on aspects such as reproducibility and practicality, and discussed advantages and weaknesses of available models for researchers who are planning to perform animal studies in the near future. Additionally, current and prospect human tissue bioengineered models are summarized.

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