Bone mineral density (BMD) T-score reference may be updated when the peak BMD of the population is unclear and may need to be updated.To update BMD T-score references using the peak BMD from the most recent National Health and Nutrition Examination Survey (NHANES) data.Cross-sectional study.The NHANES 2005-2014.Non-Hispanic white females between the ages 10-40 years (N=1549) were our target population to estimate peak BMD (SD). Individuals aged≥50 years (N=5523) were used to compare the percentages of osteoporosis and low bone mass based on existing and updated BMD T-score references.Measurements: BMD data within the age at attainment of peak BMD±5 years were used to calculate updated BMD T-score references.The updated average of BMD (SD) for diagnosing osteoporosis at the femoral neck and lumbar spine were 0.888 g/cm 2 (0.121 g/cm 2) and 1.065 g/cm 2 (0.122 g/cm 2), respectively. The percentages of individuals with osteoporosis at the femoral neck and low bone mass at the femoral neck and lumbar spine based on the updated BMD T-score references were higher than the percentages of people designated with these outcomes under the existing guidelines (P<0.001). However, we observed the opposite pattern for lumbar spine osteoporosis (P<0.001).We calculated new BMD T-score references at the femoral neck and lumbar spine. We found significant differences in the percentages of individuals classified as having osteoporosis and low bone mass between the updated and existing BMD T-score references.
Shanshan Xue, Yuzheng Zhang, Wenjing Qiao, Qianqian Zhao, Dingjie Guo, Binbin Li, Xue Shen, Lijie Feng, Fengyi Huang, Na Wang, Kemal Sherefa Oumer, Charkos Tesfaye Getachew, Shuman Yang