Age-Appropriate Cancer Screening: A Cohort Study of Adults with Psoriasis Prescribed Biologics, Adults in the General Population, and Adults with Hypertension.

Psoriasis is associated with increased risk of developing and dying from cancer.To evaluate whether psoriasis patients prescribed biologics receive the recommended screening for cervical, breast, and colon cancer.We conducted a retrospective cohort study using the Optum® de-identified Electronic Health Record dataset. Incidence rates for cervical, breast and colon cancer screening were compared between psoriasis patients prescribed biologics and two matched comparator cohorts: (1) general patient population, and (2) patients being managed for hypertension. Multivariable Cox proportional-hazards regression was performed to assess for differences in the rates of cancer screening.Compared to those in the general population without psoriasis, psoriasis patients prescribed biologics had higher screening rates for cervical cancer (adjusted hazard ratio [aHR] 1.09; 95% CI 1.02-1.16) and colon cancer (aHR 1.10; 95% CI 1.02-1.18). Compared to those with hypertension, patients with psoriasis prescribed biologics had lower screening rates for breast cancer (aHR 0.88; 95% CI 0.83-0.94) and colon cancer (aHR 0.89; 95% CI 0.83-0.95).and Relevance: Patients with psoriasis who are prescribed biologic therapies may not be receiving adequate age-appropriate cancer screening, especially for breast and colon cancer.

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