Repeat antibiotic use linked to higher risk of hospitalisation
Author: Jo Carlowe
Scientists have found a link between repeat antibiotic prescribing and a greater risk of hospitalisation.
The study*, published today in BMC Medicine finds that patients who have had nine or more antibiotic prescriptions for common infections in the previous three years are 2.26 times more likely to go to hospital with another infection in three or more months.
Funded by The National Institute for Health Research and the Connected Health Cities Programme, the study, carried out by epidemiologists from The University of Manchester, is based on the data of two million patients in England and Wales.
The patient records, from 2000 to 2016, covered common infections such as upper respiratory tract, urinary tract, ear and chest infections and excluded long-term conditions such as cystic fibrosis and chronic lung disease.
It is not clear why hospital admissions are linked to higher prescriptions and, the team say, research is needed to show what or if any biological factors exist.
The risks of going to hospital with another infection were related to the number of the antibiotic prescriptions in the previous three years. Patients who had two antibiotic prescriptions were 1.23 times more likely, patients who had three to four prescriptions were 1.33 times more likely and patients who had five to eight were 1.77 times more likely to go to hospital with another infection.
A course is defined by the team as being given over a period of one or two weeks.
Professor Tjeerd van Staa from The University of Manchester, said: "GPs care about their patients, and over recent years have worked hard to reduce the prescribing of antibiotics.
"But it is clear GPs do not have the tools to prescribe antibiotics effectively for common infections, especially when patients already have previously used antibiotics.
"They may prescribe numerous courses of antibiotics over a several years, which according to our study increases the risk of a more serious infection. That in turn, we show, is linked to hospital admissions.”
He added: "We don't know why this is, but overuse of antibiotics might kill the good bacteria in the gut (microbiota) and make us more susceptible to infections, for example.
"Prescribing antibiotics for a common infection, even though it's not certain whether it's viral - where antibiotics are not indicated - or bacterial - where they are - might be easier when there is little time.
"And in a large practice, where there is no named GP, doctors may be less likely to know their patients and less tuned in to their history and circumstances to make informed decisions.”
Clinical project manager Francine Jury also from The University of Manchester said: "GPs often have little time to get to grips with the detail of a patient's history. But what makes it even more difficult is that little official guidance exists for patients who already in the recent past had several courses of antibiotics for common infections.
"Our hope is that, however, a tool we are working for GPs, based on patient history, will be able to calculate the risks associated with taking multiple courses of antibiotics."
*van Staa, T.P., Palin, V., Li, Y. et al. The effectiveness of frequent antibiotic use in reducing the risk of infection-related hospital admissions: results from two large population-based cohorts. BMC Med 18, 40 (2020). https://doi.org/10.1186/s12916-020-1504-5