Significant fall in Hepatitis C deaths

Author: Mark Gould
Significant fall in Hepatitis C deaths

Public Health England (PHE) has welcomed new data* which reveals that deaths from Hepatitis C related liver disease fell from 380 to 319 last year, thanks to new treatments.

As well as the fall in deaths, greater access to new treatments is also linked to a reduction in the number of people with the disease requiring liver transplants. In 2017, registrations for a liver transplant due to Hepatitis C fell to a 10-year low of 63, a 53% decrease compared to pre-2015 levels.

While England has exceeded the World Health Organization’s (WHO) target to reduce Hepatitis C related mortality by 10% by 2020, PHE says challenges still exist to meet the WHO target of eliminating hepatitis C by 2030 at the latest, as there were some 113,000 people estimated to be living with chronic Hepatitis C in England in 2018.

Estimates indicate that up to 79,000 people are currently living with undiagnosed active Hepatitis C infection. PHE says this is because people with the infection often have no specific symptoms until their liver has been significantly damaged and so are unaware they are infected. When symptoms do occur, they can often be mistaken for other conditions.

The new data is to be presented today at the PHE Research and Science Conference in Manchester which will showcase innovations in public health protection.

Dr Helen Harris, senior scientist at PHE, said: "Hepatitis C infection can have devastating consequences, so the fact that more people are accessing treatment and fewer people are dying from the disease, is a huge and very welcome step forward. Yet, more needs to be done if we are to eliminate this disease as a major public health threat in England. Over a hundred thousand people in this country are thought to be living with this serious infection, and we know that significant numbers of them are unaware they are infected.

"Anyone who may be at risk of infection, in particular those who have ever injected drugs, even if they injected only once or in the past, should get tested. Given that new treatments provide a cure in around 95% of those who take them, there has never been a better time to get tested."

In 2018, PHE and NHS England launched a national exercise to identify and treat patients who have been diagnosed with Hepatitis C in the past but who may not have cleared their infections. The NHS is in the process of contacting these patients to offer testing, so those with current infection can be referred for assessment for treatment.

Professor Graham Foster, NHS national clinical lead for the Hepatitis C networks, said: "NHS England has invested several hundred million pounds to cure thousands of people with Hepatitis C, resulting in dramatic progress on saving lives and reducing the number of liver transplants.

"And, with support from drug manufacturers, there is now a real opportunity to eliminate Hepatitis C in England before the World Health Organization’s goal of 2030."

*Hepatitis C in England: 2019 report. A report prepared by Public Health England, 09 April 2019.