Green light for primary progressive MS drug

Author: Jo Carlowe
Green light for primary progressive MS drug

A new, lower price for the drug ocrelizumab has paved the way for its use on the NHS to treat primary progressive multiple sclerosis.

In final draft guidance the National Institute for Health and Care Excellence (NICE) has reversed its previous draft decision not to recommend ocrelizumab (Ocrevus, Roche) for treating primary progressive multiple sclerosis (PPMS) in adults.

This follows an agreement between the company and NHS England on the terms of a new commercial arrangement which will make ocrelizumab, the first disease-modifying treatment for PPMS, available at a lower price. The details of the commercial arrangement are confidential.

Ocrelizumab has been shown to slow the advance of PPMS, although by how much and for how long are uncertain.

Given the unmet clinical need of people with this form of MS, the cost-effectiveness estimates for ocrelizumab at the new lower price compared with best supportive care alone are in the range that NICE considers an acceptable use of NHS resources.

Meindert Boysen, director of the Centre for Health Technology Evaluation at NICE, said: “Our earlier draft guidance acknowledged that ocrelizumab represents an important development in the treatment of a condition for which there is a large unmet need. Unfortunately we couldn’t recommend it at the price offered at that time because it did not represent a cost-effective use of limited NHS resources.

“We are therefore pleased that NHS England and the company have been able to reach an agreement that will see this important new treatment made available to thousands of people with this form of MS.”

Simon Stevens, chief executive of NHS England said: “This innovative deal shows that NHS England is successfully working with companies to make treatments available for patients who need them, through flexibility and thorough negotiation.”

It is estimated that around 2,700 people could be eligible for treatment with ocrelizumab. It is given as an infusion during an outpatient appointment once every six months. The average cost per patient per year is £19,160 at its list price, based on twice yearly 600 mg infusions.

NICE published guidance last year which recommended ocrelizumab for some adults with the relapsing-remitting form of MS.

Genevieve Edwards, director of external affairs at the MS Society described the decision as “a landmark moment and an incredible victory”.