Sex and gender may affect disease prevalence, adverse effects and response to therapy.To analyse sex- and gender differences in psoriasis outpatients.A cross-sectional study was conducted at IDI-IRCCS, Rome, over a 3-year period. 3023 psoriasis patients were enrolled. Anthropometric and demographic characteristics were recorded, and a dermatologist evaluated the clinical severity of disease. Quality of life questionnaires were collected. Univariate and multivariate analyses were performed to examine factors associated with sex.We found sex- and gender- differences in clinical characteristics, severity of disease, psychological distress, and quality of life. Male sex was associated with Body Mass Index, smoking, alcohol consumption, Psoriasis Area Severity Index (PASI) 10, age at onset 20 years. Female sex was associated with family history of diabetes, joint involvement, clinical type other than plaque diffuse, higher psychological distress, and a greater burden on quality of life.Our study identified sex- and gender differences of potential clinical relevance.
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