Survival in 31 670 patients with thin melanomas - a Swedish population-based study.

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The incidence of cutaneous malignant melanoma (CMM) continues to increase in most countries worldwide and the majority are diagnosed with thin tumours (1 mm). The aim of the present study was to investigate the melanoma specific survival (MSS) as well as conditional MSS (CMSS) in patients with thin CMM in Sweden.Clinical and histologic parameters from the Swedish Melanoma Registry were obtained for patients diagnosed with thin CMM between 1990-2017. Patients were followed until the end of 2017. MSS as well as CMSS for different thickness groups were calculated using Kaplan-Meier method and Cox regression analyses were used to calculate for survival differences between thickness groups.31 670 patients were included for final analyses. The overall 10- and 20-year MSS for thin CMMs was 97% (95% CI 97-97) and 95% (95% CI 95-96) respectively. From 07 mm and above, MSS decreased significantly with increasing thickness level. All thickness groups had an increased survival over time. The lowest CMSS was confirmed for men with 10 mm in thickness but their 10-year CMSS steadily increased over time. Women had overall better MSS as well as CMSS than men. However, the relation between MSS and CMSS was similar for both sexes.Long-term MSS was confirmed excellent for patients with thin CMMs in Sweden. Although we could show a decreased MSS for patients with 07 mm and above, the long-term survival and in addition a very favourable CMSS for those patients, do not support more extended follow-up programs than current recommendations in Sweden.


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