Testosterone administration during energy deficit suppresses hepcidin and increases iron availability for erythropoiesis.

Like Comment

Severe energy deprivation markedly inhibits erythropoiesis by restricting iron availability for hemoglobin synthesis.The objective of this study was to determine whether testosterone supplementation during energy deficit increased indicators of iron turnover and attenuated the decline in erythropoiesis compared to placebo.This was a 3-phase, randomized, double-blind, placebo-controlled trial.The study was conducted at the Pennington Biomedical Research Center.Fifty healthy young males.Phase 1 was a 14-d free-living, eucaloric controlled-feeding phase; phase 2 was a 28-d inpatient phase were participants were randomized to 200 mg testosterone enanthate/week or an isovolumetric placebo/week during an energy deficit of 55% of total daily energy expenditure; phase 3 was a 14-d free-living, ad libitum recovery period.Indices of erythropoiesis, iron status, and hepcidin and erythroferrone were determined.Hepcidin declined by 41%, indicators of iron turnover increased, and functional iron stores were reduced with testosterone administration during energy deficit compared to placebo. Testosterone administration during energy deficit increased circulating concentrations of erythropoietin and maintained erythropoiesis, as indicated by an attenuation in the decline in hemoglobin and hematocrit with placebo. Erythroferrone did no differ between groups, suggesting that the reduction in hepcidin with testosterone occurs through an erythroferrone-independent mechanism.These findings indicate that testosterone suppresses hepcidin, through either direct or indirect mechanisms, to increase iron turnover and maintain erythropoiesis during severe energy deficit. This trial was registered at www.clinicaltrials.gov as #NCT02734238.

Click here to read the full article @ The Journal of clinical endocrinology and metabolism

ClinOwl

The wider, wiser view for healthcare professionals. ClinOwl signposts the latest clinical content from over 100 leading medical journals.
3882 Contributions
1 Followers
0 Following

No comments yet.