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Clinical articles

Our clinical articles provide comprehensive overviews of a large range of clinical topics and include helpful key learning points. Log your learning in your PDP tracker to claim CME credits.

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MHRA issues several drug safety updates, including on direct-acting oral anticoagulants, and GLP-1 receptor agonists; NICE now recommends blinatumomab for acute lymphoblastic leukaemia
NICE recommends ocrelizumab for primary progressive multiple sclerosis in final guidance; SMC accepts nivolumab in combination with ipilimumab for advanced renal cell carcinoma
NICE recommends ertugliflozin in triple therapy for type 2 diabetes; recommendations published on the use of paclitaxel drug-coated balloons and drug-eluting stents
A overview of the third most common cancer in the UK, covering epidemiology, presentation, investigation, staging, management and prognosis
NICE recommends letermovir to prevent cytomegalovirus disease in draft guidance; EMA gives positive opinion for Cufence for Wilson’s disease; NHS England announces more than 50,000 people use Personal Health Budgets
MHRA issues drug safety updates on magnesium sulfate, tofacitinib and alemtuzumab (Lemtrada); primary hyperparathyroidism NICE guideline published; EMA announces withdrawal of marketing authorisations for fenspiride medicines
A review of the definition, aetiology and assessment of delirium, including the role of good history taking, screening tools, examination and investigations.
A review of the causes, assessment and treatment of this common medical emergency that has a 10% hospital mortality rate
Lenalidomide now recommended for multiple myeloma in two pieces of NICE final draft guidance; MHRA issues class 2 medicines recall: Co-amoxiclav for oral suspension variants
Previous decision reversed for ocrelizumab for primary progressive multiple sclerosis in NICE final draft guidance; company-led drug alert issued for Macopharma intravenous infusion bags
A summary of the risk factors and management options for this very common condition
New and updated NICE guidelines published: recognition and referral of suspected neurological conditions and diagnosis and initial management of strokes and TIA; EMA recommends new long-lasting implant to treat opioid dependence
A clinical review of the classification, investigations, and management of a condition affecting about 600,000 people in UK. This article also includes considerations about pregnancy and the GP responsibility with the DVLA.
Accurately diagnosing a TIA can be quite difficult as the diagnosis is largely based on history from the patient. This clinical review includes the latest NICE guidance on imaging and the role of urgent carotid endarterectomy.
NICE final guidance recommends brentuximab vedotin for CD30‑positive cutaneous T‑cell lymphoma; MHRA issues medicines defect information for Ativan 4mg/1ml Solution for injection
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