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Three genes linked to gout risk

Combined up to 40-fold increased genetic risk

OnMedica Staff

Wednesday, 01 October 2008

US researchers have identified three genes that can increase the risk of gout 40-fold,.

The researchers from the National Heart, Lung and Blood Institute in Maryland identified two new genes and confirmed the role of a third gene linked to increased risk of higher levels of uric acid in the blood. The three genes combined were associated with up to a 40-fold increased risk in developing gout.

The results published in the Lancet today involved data from nearly 7,700 people involved in the Framingham Heart Study and more than 4,100 participants in the Rotterdam Study. The findings were then replicated in 14,900 participants of the Atherosclerosis Risk in Communities Study.

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