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Maternal stress affects baby’s brain development

‘More support needed for expectant mums’

Jo Carlowe

Wednesday, 09 October 2019

New research published this week suggests maternal stress before and during pregnancy could affect a baby's brain development.

In their study* published in Biological Psychiatry, MRC doctoral researcher in perinatal imaging and health, Alexandra Lautarescu and head of advanced neuroimaging, Professor Serena Counsell, of King’s College London, looked at the relationship between maternal stress and brain development in 251 premature babies.


They found evidence for impaired development of the uncinate fasciculus in babies whose mothers experienced more stress in the prenatal period.

The mothers completed a questionnaire which asked them about their experiences of stressful events, which ranged from everyday stress such as moving house or taking an exam, to more severe stressors like experiencing bereavement, separation or divorce.

A score of severity of stress was calculated based on how many stressors they experienced as well as how severe those stressors were.

The researchers then used diffusion tensor imaging, developed to look at the structure of the white matter. White matter tract has previously been implicated in anxiety disorders.

”We found that in the mums that were more stressed during pregnancy and the period before birth, white matter was altered in the babies," said lead researcher Alexandra Lautarescu.

Scientists say the study highlights the importance of providing support for expectant mothers, as previous studies have shown that interventions such as cognitive behavioural therapy can help mitigate adverse outcomes in the baby.

The authors note that while expectant mothers may be asked questions about depressive symptoms, few questions are asked about general stress and anxiety. Women who deal with stressful life events during pregnancy are not picked up by their GPs or by their health care providers very often.

"It is not diagnosed as often as it should be during pregnancy and we are trying to emphasise that maternal mental health during pregnancy can impact the baby's brain development which may impact on their outcomes later in life," said Alexandra Lautarescu.

“No-one is asking these women about stress and hence they don't receive any support.

"Antenatal services need to be aware that it is important to think about stress… If we try to help these women either during the pregnancy or in the early post-natal period with some sort of intervention this will not only help the mother, but may also prevent impaired brain development in the baby and improve their outcomes overall.”

Further studies are needed to understand whether the observed changes in the brain development of these babies will lead to adverse outcomes later in life.


*Lautarescu A, Nosarti C, Nihouarn J, et al. Maternal Prenatal Stress Is Associated With Altered Uncinate Fasciculus Microstructure in Premature Neonates. Biological Psychiatry, 23 August 2019. DOI:10.1016/j.biopsych.2019.08.010

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